Methods: To develop a comprehensive therapy for MSMDS, we utilized CRISPR-Cas9 adenine base editing to correct the ACTA2 R179H mutation. We generated isogenic human induced pluripotent stem cell (iPSC ...

Department of Cardiology and Institute of Vascular Medicine, Peking University Third Hospital, Beijing, China (Y. Zheng, Y.C., W.W., Y.T., C.L., M.Z., Y.S., Y.-g.-s.W ...

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In the recent article, “Antisense Oligonucleotide Therapy for Calmodulinopathy,” we provided the first proof-of-concept in vivo evidence that depletion of CALM1 safely and effectively treated ...

Such findings were generally ignored because multiple epidemiological studies have demonstrated reduced cardiovascular disease (CVD) events with increasing levels of physical activity (PA). Randomized ...

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Division of Cardiology, Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles. (J.M.C., K.V., S.-K.P., E.Z., P.Z., T.Y., T.K ...

Elevated plasma levels of Lp(a) [lipoprotein(a)] are a causal risk factor for coronary heart disease and stroke in European individuals, but the causal relevance of Lp(a) for different stroke types ...

Department of Neurology, Division of Neurocritical Care and Stroke Service, Center for Neurotechnology and Neurorecovery, Massachusetts General Hospital, Harvard Medical School, Boston (D.J.L.).

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Clinical effectiveness of catheter ablation in atrial fibrillation (AF) is typically characterized by 12-month freedom from atrial tachyarrhythmia recurrence. However, freedom from AF burden may serve ...