BACKGROUND: Desmosomal gene variants (DGVs) have been associated with a diverse spectrum of phenotypic manifestations within ...

Cardiac intensive care units are witnessing a demographic shift, characterized by patients with increasingly complex or ...

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Methods: To develop a comprehensive therapy for MSMDS, we utilized CRISPR-Cas9 adenine base editing to correct the ACTA2 R179H mutation. We generated isogenic human induced pluripotent stem cell (iPSC ...

Department of Cardiology and Institute of Vascular Medicine, Peking University Third Hospital, Beijing, China (Y. Zheng, Y.C., W.W., Y.T., C.L., M.Z., Y.S., Y.-g.-s.W ...

Department of Neurology, Division of Neurocritical Care and Stroke Service, Center for Neurotechnology and Neurorecovery, Massachusetts General Hospital, Harvard Medical School, Boston (D.J.L.).

Background: The PRAETORIAN trial investigated the efficacy and safety of the subcutaneous implantable cardioverter-defibrillator (S-ICD) compared with transvenous ICD (TV-ICD) and showed ...

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Arteriovenous malformations (AVMs) and intracranial aneurysms contribute to a high degree of morbidity and mortality due to the risk of intracranial hemorrhage observed in each of these ...

Such findings were generally ignored because multiple epidemiological studies have demonstrated reduced cardiovascular disease (CVD) events with increasing levels of physical activity (PA). Randomized ...

There is no evidence evaluating efficiency, effectiveness, and safety outcomes in older patients in the context of pulsed‐field ablation technology for the ablation of atrial fibrillation. We aimed to ...