Joshua Zirkzee, who had also been ruled out through the end of the campaign after injuring his hamstring, was a surprise appearance in team training at Carrington on Tuesday. Given the extended absence, the Dutch forward might be more likely to start on the bench in Spain, with Rasmus Højlund in line to start.

Just like Spurs, Manchester United have been beyond abysmal in the Premier League but they are at their best when playing in Europe. Tottenham have beaten United three times this season, winning 3-0 at Old Trafford in September, 1-0 in N17 in February and 4-3 in the Carabao Cup in December.