State Key Laboratory of Membrane Biology, Institute of Molecular Medicine, College of Future Technology, Peking University, China. (Q.H., J.L., F.L., L.J., P.X., W ...

Duke Congenital Heart Surgery Research and Training Laboratory, Duke University, Durham, NC (N.K.P., B.A., M.M.-M., D.M.O., J.W.T.). Department of Surgery, Duke ...

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Methods: To develop a comprehensive therapy for MSMDS, we utilized CRISPR-Cas9 adenine base editing to correct the ACTA2 R179H mutation. We generated isogenic human induced pluripotent stem cell (iPSC ...

Department of Cardiology and Institute of Vascular Medicine, Peking University Third Hospital, Beijing, China (Y. Zheng, Y.C., W.W., Y.T., C.L., M.Z., Y.S., Y.-g.-s.W ...

Medical Faculty Heidelberg, Institute of Experimental Cardiology, Heidelberg University, Germany. (M.E.P., P.J.M.K., S.N., F.B., F.S., M.D., J.B.) Department of ...

ED indicates emergency department; CP, chest pain. Data were not reported for items left blank. Defined using creatine kinase-MB in all sources, except troponin was used in References 6 and 8.

Such findings were generally ignored because multiple epidemiological studies have demonstrated reduced cardiovascular disease (CVD) events with increasing levels of physical activity (PA). Randomized ...

Gu et al caution that results in immature hiPSC-CMs may not predict efficacy in mature cardiomyocytes. Although hiPSC-CMs lack some features of mature cardiomyocytes, 3 they share similar molecular ...

The recent study by Bortolin et al, 1 “Antisense Oligonucleotide Therapy for Calmodulinopathy,” presents an innovative therapeutic strategy for rare inherited arrhythmia syndromes. By leveraging ...

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