The consequences of DNA damage depend on the cell type and the severity of the damage. Mild DNA damage can be repaired with or without cell-cycle arrest. More severe and irreparable DNA injury ...

While most known types of DNA damage are fixed by our cells’ in-house DNA repair mechanisms, some forms of DNA damage evade repair and can persist for many years, new research shows. This ...

This review gives an account of how the cell repairs DNA damage and presents evidence that DNA damage contributes to aging and cancer, with the outcome dependent on the type and number of lesions i ...

Taking Snapshots of DNA Damage in Skin Cancer Researchers turn to high resolution sequencing to explain recurrent melanoma mutations caused by UV exposure.

Alkylating agents produce specific types of DNA damage, and Aag glycosylase normally initiates repair of such damage.

Studies conducted in yeast show that exposure to ultraviolet light (UV) induces new types of DNA damage that may cause the deadliest form of skin cancer, malignant melanoma.

One type of genetic damage is known as crosslinking, in which the nucleotide bases of DNA get stuck together. The double helix of DNA has to be unwound and separated when a cell is dividing and ...

DNA damage in cancer cells targeted to kill them Chromosomal rearrangements—a hallmark of tumor cells—make the cells a target.

At the University of Copenhagen, researchers have discovered how some types of proteins stabilize damaged DNA and thereby preserve DNA function and integrity. This new finding also explains why ...