BACKGROUND: Desmosomal gene variants (DGVs) have been associated with a diverse spectrum of phenotypic manifestations within ...

Cardiac intensive care units are witnessing a demographic shift, characterized by patients with increasingly complex or ...

State Key Laboratory of Membrane Biology, Institute of Molecular Medicine, College of Future Technology, Peking University, China. (Q.H., J.L., F.L., L.J., P.X., W ...

Duke Congenital Heart Surgery Research and Training Laboratory, Duke University, Durham, NC (N.K.P., B.A., M.M.-M., D.M.O., J.W.T.). Department of Surgery, Duke ...

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Methods: To develop a comprehensive therapy for MSMDS, we utilized CRISPR-Cas9 adenine base editing to correct the ACTA2 R179H mutation. We generated isogenic human induced pluripotent stem cell (iPSC ...

Department of Cardiology and Institute of Vascular Medicine, Peking University Third Hospital, Beijing, China (Y. Zheng, Y.C., W.W., Y.T., C.L., M.Z., Y.S., Y.-g.-s.W ...

Department of Molecular Pharmacology and Physiology, Morsani College of Medicine, University of South Florida School of Medicine, Tampa. For Sources of Funding and Disclosures, see page 1611.

Septic shock is associated with increases in end‐diastolic volume (EDV) and decreases in ejection fraction that reverse within 10 days. Nonsurvivors do not develop EDV increases. The mechanism is ...

Atrial fibrillation detected after stroke (AFDAS) affects secondary stroke prevention, yet identification can be challenging. Easily accessible cardiac blood biomarkers such as NT-proBNP (N-terminal ...

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Background: The PRAETORIAN trial investigated the efficacy and safety of the subcutaneous implantable cardioverter-defibrillator (S-ICD) compared with transvenous ICD (TV-ICD) and showed ...