Route 66 could leave that kind of mark on travelers. The road went in two directions between Chicago and Los Angeles, but its legacy remains its role in opening up the west to 20th-century America.

Route 66 might be best known for its classic Americana, vintage motels, and endless roadside attractions—but these photos tell a deeper story. Photographer Anthony Presley captures the quieter ...

'Route 66: The Road and the Romance' at the Autry takes a national perspective on America's 'Main Street' with 250-plus artifacts.

Route 66 represents America’s adolescence, a time of exploring and trying new things and forming our personalities. Route 66 is where America learned to drive.

Route 66 has been called “the most famous highway in the world,” and it remains the ultimate road trip, as described in the new book, “Route 66 Still Kicks.” ...

After going through Afton in northeast Oklahoma, Route 66 heads straight across the state line to Neosho, Mo., where it turns north toward Joplin without going through Kansas at all.

Prairie grass sways in the wind. Route 66, commissioned in 1926 through the National Highway Act, is 75 years old this year. Tell it to the road. Officially, it is no longer a designated U.S. highway.

Our Route 66 road trip ended at the beginning, at East Jackson Boulevard and South Michigan Avenue in Chicago, where a brown sign hanging 12 feet high on a light post tells people they’ve ...

Oklahoma City is looking at creating a Route 66 landmark attraction that will celebrate the city's ties to the "Get your ...

Route 66 car show sets stage for fabled road's centennial Organizer Reggie Tibbetts expects cars "from all across the nation" at next year's show.