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Mariners vs Astros Picks, Odds and Prediction

Mariners at Astros Prediction: Odds, expert picks, starting pitchers, betting trends and stats for May 22

George Kirby is slated to take the mound for Seattle against Lance McCullers for Houston.The Astros are hoping to bounce back from an 8-4 loss and a dropped series against the Tampa Bay Rays when McCullers takes the mound today.

FOX Sports · 18h

Mariners vs. Astros Prediction, Odds, Picks - May 22

Preview the May 22 matchup between the Seattle Mariners and Houston Astros with odds over/under, game spread, betting lines and more.

The Indianapolis Star · 17h

Seattle Mariners at Houston Astros odds, picks and predictions

The Mariners picked up a 6-5 win Wednesday on the road against the Chicago White Sox, securing a series win with a second victory. The M's cashed as a moderate (-145) favorite as the Over (8.5) connected.

Mariners lose George Kirby’s debut

Sports Illustrated on MSN · 7h

Seattle Mariners Fall in George Kirby's Season Debut, Lose 9-2 to Houston Astros

The Mariners were unable to hold an early lead as the Astros got to the former All-Star pitcher in his first game back from a shoulder injury.

The Seattle Times · 8h

Mariners lose George Kirby’s debut; Julio Rodríguez scratched vs. Astros

George Kirby’s return to the mound ended in a loss and Julio Rodríguez was scratched from the lineup as the Mariners were thumped by the Astros.

Associated Press News on MSN · 7h

George Kirby returns to the mound but struggles in Mariners’ loss to Astros

Seattle’s George Kirby didn’t get the results he wanted in his season debut against the Houston Astros but was still encouraged in his return to the mound after a lengthy absence.

6hon MSN

Altuve's 2 homers and Peña's milestone triple propel Astros past Mariners 9-2

HOUSTON - Jose Altuve homered twice and drove in a season-high four runs and Jeremy Peña tripled for his 500th career hit to ...

9hon MSN

Mariners Make Unfortunate Julio Rodriguez Announcement Before Astros Game

Mariners Make Unfortunate Julio Rodriguez Announcement Before Astros Game first appeared on Athlon Sports on May 22, 2025 ...

8hon MSN

Jose Altuve's two homers help Houston Astros get important win over Seattle Mariners

Jose Altuve had the 12th multi-homer game of his career to spark Houston over Seattle in a match atop AL West.

Mariners await positive pitching news amid series in Houston

The series opener against the host Houston Astros on Thursday resulted in a loss for the Mariners as a team, but the Seattle rotation took a step forward.

22h

How to Watch Mariners vs. Astros: TV Channel & Live Stream - May 22

Preview the May 22 matchup between the Seattle Mariners and Houston Astros with recent trends, how to watch, livestream info, ...

14h

Mariners vs. Astros Starting Pitcher Matchup - May 22

This affiliate content is not influenced by our advertising relationships, but AP and Data Skrive might earn commissions from ...

21h

Where to Watch the Astros vs. Mariners Series: TV Channel, Live Stream, Game Times and more

Find out how to watch the Houston Astros vs. Seattle Mariners series, with TV channel info, live streaming options, game ...

1don MSN

Seattle Mariners' Rival Dealing with Another Injury Issue Before Huge Weekend Series

The Seattle Mariners are about to finish up their 10-game road trip with four games in Houston against the Astros, and ...

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